Regulation of the Hippo Pathway Transcription Factor TEAD
نویسندگان
چکیده
منابع مشابه
Targeting the Hippo Pathway and Cancer through the TEAD Family of Transcription Factors
The Hippo pathway is a critical transcriptional signaling pathway that regulates cell growth, proliferation and organ development. The transcriptional enhanced associate domain (TEAD) protein family consists of four paralogous transcription factors that function to modulate gene expression in response to the Hippo signaling pathway. Transcriptional activation of these proteins occurs upon bindi...
متن کاملAutopalmitoylation of TEAD Proteins Regulates Transcriptional Output of Hippo Pathway
TEA domain (TEAD) transcription factors bind to the coactivators YAP and TAZ and regulate the transcriptional output of the Hippo pathway, playing critical roles in organ size control and tumorigenesis. Protein S-palmitoylation attaches a fatty acid, palmitate, to cysteine residues and regulates protein trafficking, membrane localization and signaling activities. Using activity-based chemical p...
متن کاملThe TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control.
The Hippo (Hpo) signaling pathway governs cell growth, proliferation, and apoptosis by controlling key regulatory genes that execute these processes; however, the transcription factor of the pathway has remained elusive. Here we provide evidence that the TEAD/TEF family transcription factor Scalloped (Sd) acts together with the coactivator Yorkie (Yki) to regulate Hpo pathway-responsive genes. ...
متن کاملMechanisms of Hippo pathway regulation.
The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue growth two decades ago and has been a subject extensively studied in both Drosophila and mammals in the last several years. The core of the Hippo pathway consists of a kinase cascade, transcription coactivators, and DNA-binding partners. Recent studies have expanded the Hippo pathway as a complex signaling ...
متن کاملThe Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain.
The transcriptional coactivator Yes-associated protein (YAP) is a major regulator of organ size and proliferation in vertebrates. As such, YAP can act as an oncogene in several tissue types if its activity is increased aberrantly. Although no activating mutations in the yap1 gene have been identified in human cancer, yap1 is located on the 11q22 amplicon, which is amplified in several human tum...
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ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2017
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2017.09.003